High Throughput Screening Cherry Picking

HTS Cherry Picking

High Throughput Screening (HTS) applications usually involve several steps. The first series of steps is to prep the primary screen from the master plate, also known as "Mother Plate" from its current format - typically 96 or 384 well Microtiter Plate (MTP) and either duplicate or reformat it into a higher density plate (ie 384 or 1536 well MTP). After the replications are created, the primary screen across the plate is run. Based on the results of the screen, researchers may then choose to select content from a specific well (ie "Cherry Picking") and create a new MTP. To efficiently perform this step, an Easy to Use graphical interface is needed, allowing the user to select from a "graphical map" which well to have the system aspirate from, and then select which well, to dispense the material to.

By combining both the ability to do the replication/reformatting steps with disposable tips, users can quickly and safely transfer their screens to new plates. Following of the outcome of the screen, they can then use the same system, with an independent aspirate and dispense channel, and select which well to "cherry pick" from, and where, and how much to dispense into the new plates.