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Home > Application > Biosensor > Introduction

INTRODUCTION

Following advances in microelectronics, biosensor designs are becoming increasingly complex, and focused on miniaturization. The demand for simultaneous measurement of multiple analytes has stimulated development of high density arrays. As a result of this demand, and the advancing capabilities of patterning technologies, research and development programs aimed at sensor arrays containing multiple biomarkers in devices on the order of a square centimeter are underway. Fabrication of these devices typically requires reagent-dispensing approaches capable of delivering volumes ranging from the low microliters to picoliters. Reductions in volume reduce cost of expensive reagents, increase surface dependant reaction rates, and promote adoption of multiplexed diagnostic devices. Dispensing systems used must be compatible with a wide range of reagent classes, including organic solvents, biological fluids, polymeric solutions, as well as the traditional combination of buffer and enzymes. Systems must be robust enough to produce hundreds of thousands to millions of dispenses with a high level of precision and accuracy. Lastly these systems must function in a production environment using less skilled labor and also subject to rigorous regulatory requirements.

The Glucose biosensor is probably the most common of biosensors where the typical format is a “sheet” and the reagent is dispensed to a pre-printed electrode pattern. In many biosensor applications, multiple layers of different samples are dispensed in different steps requiring great flexibility as well as high positional accuracy. The sample is allowed to dry down and then is cut, and packaged.

INTRODUCTION

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